In this paper, I examine some of the most important theories of modern physics that support the notion that events are the basic ontological units of reality. The two main themes of this paper include: (1) physical evidence in support of an ontology of events, and (2) the increasing unification of physical theory until we arrive at the current state of two highly successful theories that are presently disunified within the search for a comprehensive, unified theory. With the revolutionary developments (...) in physics at the end of the nineteenth century, the mechanistic materialism of Newtonian physics began to break down and the ancient trinity of space, time and matter has been gradually replaced by the notion of the energy field. Physicists and philosophers who have held an event ontology specifically for its compatibility with electromagnetism, relativity theory and quantum mechanics include: Albert Einstein, Alfred North Whitehead, Bertrand Russell, C. D. Broad, W. V. Quine, John Bell, Henry Stapp, and Milič Čapek among many others. For these theorists, events are the most fundamental entities of physical reality in contrast to the Aristotelian tradition which contends that events are secondary or dependent on physical substance. (shrink)

Bradley and Whitehead certainly deserve a book-length comparison on such topics as experience, internal and external relations, particularly whole-part relations, time, and God. Leemon McHenry has explored these issues soberly and responsibly, and his conclusions are most informative. Yet I sometimes wonder whether the connection would be as firmly made had there not been one remark about Bradley in the preface to Process and Reality.

Medical ghostwriting is the practice in which pharmaceutical companies engage an outside writer to draft a manuscript submitted for publication in the names of “honorary authors,” typically academic key opinion leaders. Using newly-posted documents from paroxetine litigation, we show how the use of ghostwriters and key opinion leaders contributed to the publication of a medical journal article containing manipulated outcome data to favor the proprietary medication. The article was ghostwritten and managed by SmithKline Beecham, now GlaxoSmithKline (GSK) and Scientific Therapeutics (...) Information, Inc. without acknowledging their contribution in the published article. The named authors with financial ties to GSK, had little or no direct involvement in the paroxetine 352 bipolar trial results and most had not reviewed any of the manuscript drafts. The manuscript was originally rejected by peer review; however, its ultimate acceptance to the American Journal of Psychiatry was facilitated by the journal editor who also had financial ties to GSK. Thus, GSK was able to take an under-powered and non-informative trial with negative results and present it as a positive marketing vehicle for off-label promotion of paroxetine for bipolar depression. In addition to the commercial spin of paroxetine efficacy, important protocol-designated safety data were unreported that may have shown paroxetine to produce potentially harmful adverse events. (shrink)

All’inizio del secolo XX, tre filosofi di Cambridge, Alfred North Whitehead, Bertrand Russell, e Charlie Dunbar Broad, sostennero un’ontologia basata sugli eventi che si riteneva fosse compatibile con la recente teoria della relatività . Gli eventi, perciò, rimpiazzavano le sostanze aristoteliche in veste di componenti primari dell’universo – essi erano concepiti come unità di spazio-tempo che si estendevano spazio-temporalmente e che si sovrapponevano al campo elettromagnetico. Via via che la fisica moderna progrediva, le ontologie basate sugli eventi sembrarono guadagnare ulteriore (...) supporto dal comportamento inaspettato delle particelle elementari descritte a livello quantistico. Dall’espansione dell’universo alle traiettorie delle particelle subatomiche, sembrava che tutto potesse essere sistematicamente interpretato in termini di eventi. (shrink)

Editorial independence is a bedrock principle of academic publishing. The growing domination of academic publishing by large, for-profit corporations threatens this independence. There is alarming evidence that large companies too often serve their own business interests and those of powerful clients rather than serving the scientific community and the general public. This evidence includes the publication of infelicitous commercial science and concealing scientific misconduct. We present two case studies in which the UK-based publisher Taylor & Francis interfered in the editorial (...) process by blocking publication of legitimate criticism that had been reviewed and approved for publication by its specialized editors. The integrity of science depends in part on the transparency and intellectual honesty of all stakeholders. The widely acknowledged inadequacies of English libel law are reviewed as context for some of Taylor & Francis’s fearful decisions. (shrink)

Nicholas Maxwell's provocative and highly-original philosophy of science urges a revolution in academic inquiry affecting all branches of learning, so that the single-minded pursuit of knowledge is replaced with the aim of helping people realize what is of value in life and make progress toward a more civilized world. This volume of essays from an international, interdisciplinary group of scholars engages Maxwell in critical evaluation and celebrates his contribution to philosophy spanning forty years. Several of the contributors, like Maxwell, took (...) their inspiration from Sir Karl Popper’s philosophy of science and were connected to the department he created at the London School of Economics. In the introductory chapter, Maxwell provides an overview of his thought and then defends his views against objections in a concluding essay. -/- . (shrink)

This essay compares the fundamental metaphysical principles, the Categoreal Scheme of A. N. Whitehead's Process and Reality with the axiomatic-deductive scheme of Whitehead and Russell's Principia Mathematica to reveal the influence of mathematical logic on Whitehead's metaphysics.

Recent developments in cosmology and particle physics have led to speculation that our universe is merely one of a multitude of universes. While this notion, the multiverse hypothesis, is highly contested as legitimate science, it has nonetheless struck many physicists as a necessary consequence of the effort to construct a final, unified theory. In Process and Reality (1929), his magnum opus, Alfred North Whitehead advanced a cosmology as part of his general metaphysics of process. Part of this project involved a (...) theory of cosmic epochs which bears a remarkable affinity to current cosmological speculation. This paper demonstrates how the basic framework of a multiverse theory is already present in Whitehead’s cosmology and defends the necessity of speculation in the quest for an explanatory description. (shrink)

In this case study from litigation, I examine the origin of Monsanto-sponsored articles published in toxicology journals and the lay media that were designed to create doubt in critical evaluations of the herbicide, glyphosate. The role of ghostwriting and the use of third-party academics in the corporate defense of glyhphosate reveal that this practice extends beyond the corruption of medical journals and persists in spite of efforts to enforce transparency in industry manipulation of the scientific literature.

F. H. Bradley's metaphysical monism stands on the basis of his arguments against individuality and relations. In this essay, I argue that Bradley's arguments are flawed and make a case for the reality of asymmetrical, temporal relations via the process metaphysics of A. N. Whitehead.

Selective reporting is prevalent in the medical literature, particularly in industry-sponsored research. In this paper, we expose selective reporting that is not evident without access to internal company documents. The published report of study 329 of paroxetine in adolescents sponsored by GlaxoSmithKline claims that “paroxetine is generally well tolerated and effective for major depression in adolescents”. By contrast, documents obtained during litigation reveal that study 329 was negative for efficacy on all 8 protocol specified outcomes and positive for harm.

In his magnum opus, Process and Reality, Alfred North Whitehead claims a special affinity to Oxford philosopher Francis Herbert Bradley. McHenry clarifies exactly how much of Whitehead's metaphysics is influenced by and accords with the main principles of Bradley's "absolute idealism." He argues that many of Whitehead's doctrines cannot be understood without an adequate understanding of Bradley, in terms of both affinities and contrasts. He evaluates the arguments between them and explores several important connections with William James, Josiah Royce, (...) George Santayana, Bertrand Russell, and Charles Hartshorne. (shrink)

Despite growing concern about medical ghostwriting, pharmaceutical companies, universities, medical journals, and communication companies employing ghostwriters have thus far failed to adequately stem the problem. As a result, some commentators have proposed that legal remedies could be sought by patients harmed by drugs publicized in ghostwritten papers. In this Essay, we build on a recent analysis by Stern and Lemmens in PLoS Medicine to outline specific areas of legal liability.

In this Festschrift honoring the work of Timothy L. S. Sprigge, Sprigge summarizes his philosophy (a synthesis of absolute idealism, panpsychism, and utilitarianism), defends his position against criticism raised by philosophers in the preceding chapters of this volume, and offers in an addendum a proof for the existence of the Absolute, namely, a final and all-embracing Consciousness akin in many ways to Spinoza’s God. This defense of his philosophy consists mainly of responses to various points of criticism raised about his (...) view of time, the relation between his metaphysics and ethics, panpsychism, the Absolute, and animal rights. (shrink)

This case study reports an instance of SmithKline Beecham's behind-the-scenes ghostwriting a letter to the editor in a medical journal article in the name of an academic physician. In order to respond to criticism that paroxetine caused severe withdrawal effects, SmithKline Beecham's marketing department hired a PR firm to ghostwrite three separate letters to spin a favorable impression of paroxetine vs fluoxetine and published one in the Journal of Clinical Psychiatry.

Alfred North Whitehead advanced a version of multiverse theory in 1929 that bears a remarkable affinity to the revolutionary ideas of current cosmological speculation. He postulated his theory for some of the very same reasons as those advanced today by leading cosmologists and physicists such as Martin Rees, Lee Smolin, Stephen Hawking, Max Tegmark and Steven Weinberg, but his theory has largely gone unnoticed.

Ghostwriting for medical journals has become a major, but largely invisible, factor contributing to the problem of credibility in academic medicine. In this paper I argue that the pharmaceutical marketing objectives and use of medical communication firms in the production of ghostwritten articles constitute a new form of sophistry. After identifying three distinct types of medical ghostwriting, I survey the known cases of ghostwriting in the literature and explain the harm done to academic medicine and to patients. Finally, I outline (...) steps to address the problem and restore the integrity of the medical literature. (shrink)

We live in an age alleged devoted to evidence-based medicine. Evidence-based medicine, however, depends on reliable data and if the data are largely, if not completely, manipulated by the manufacturer of pharmaceuticals, then the data are not reliable. Evidence-based medicine is an illusion. This book raises and attempts to answer the following questions: What are the ways in which the profit motive of industry undermines the integrity of science? How is science protected from corporate malfeasance in a capitalist economy? Our (...) particular focus is the relationship between the pharmaceutical industry and medicine. We argue that medicine desperately needs to re-evaluate its relationship with the pharmaceutical industry and re-affirm the ideal of evidence-based medicine. In our view, Karl Popper’s philosophy of science, Falsificationism and Critical Rationalism, provides a rigorous conception of science required to preserve the integrity of the scientific basis of medicine against the commercial influences. (shrink)

Karl Popper's celebrated theory of falsification provides a rigorous view of science but it has been criticized as failing to explain how science makes progress. In this essay, I compare Popper's falsificationism with Nicholas Maxwell's aim-oriented empiricism and examine the role that metaphysics plays in explaining scientific progress.

W.V.O. Quine and A.N. Whitehead shared a dualistic ontology of concrete and abstract objects but differed sharply on the status of properties. In this essay, we explore Whitehead’s reasons for admitting properties into his ontology and Quine’s objections. In the course of examining Quine’s position we demonstrate some deficiencies in his position and conclude that in spite of his claims, neither space-time coordinate systems nor classes can do all the ontological work of properties.

In this volume of the Dictionary of Literary Biography, notable philosophers of the Anglo-American tradition, analytical philosophy, are represented as well as other philosophers who made significant contributions to American philosophy in the latter half of the twentieth century.

In this volume of the Dictionary of Literary Biography, early philosophers of the classical period, the "golden age," are represented as well as a number of other figures whose contributions gave shape and direction to philosophy in America in the nineteenth and twentieth century.

Biomedical ethics requires that clinical trial participants be accurately informed of the potential risks associated with investigational medical products. We found that the vaccine manufacturer Merck made false statements to the trial participants about the safety of Gardasil in its Future II HPV vaccine trial in Denmark. The clinical study protocol specified that safety testing was one of the trial’s primary objectives, but the recruitment brochure given to trial participants stated this was not the case, as allegedly the vaccine had (...) already been proven safe in previous trials. The advertising material for the trial and the informed consent forms stated that the comparator was saline or an inactive substance, when, in fact, it contained Merck’s proprietary aluminum adjuvant which is highly immunogenic. Several trial participants experienced long-term disabling symptoms during the trial, also some randomized to the adjuvant “placebo” control group. In all cases, their serious adverse events were dismissed as unrelated to the study treatment by Merck’s clinical investigators. We demonstrate that Merck’s published statements about the safety of their proprietary aluminum adjuvant is contradicted by the research evidence. The use of adjuvants as “placebos” in vaccine clinical trials is unethical as it makes it difficult to discover serious vaccine harms. (shrink)

In this monograph, I argue that Whitehead's metaphysics provides a more adequate basis for achieving a unification of physical theory than a traditional substance metaphysics. I investigate the influence of Maxwell's electromagnetic field, Einstein's theory of relativity and quantum mechanics on the development of the ontology of events and compare Whitehead’s theory to his contemporaries, C. D. Broad and Bertrand Russell, as well as another key proponent of this theory, W. V. Quine. In this manner, I defend the naturalized and (...) speculative approach to metaphysics as opposed to analytical and linguistic methods that arose in the 20th century. (shrink)

In this essay I make a case for a number of common themes between A. N. Whitehead and W. V. Quine in their approach to ontology. Both philosophers espoused a view of metaphysics as continuous with natural science and stressed the importance of physics in the development of ontology. As a consequence of the revolutionary developments in modern physics, both Whitehead and Quine contend that events are ontologically basic, but differ on the status of properties in their respective systems.

Corporate interests corrupt clinical trials, physicians and universities, undermining the foundation of evidence-based medicine. Philosopher Leemon McHenry and psychiatrist Jon Jureidini argue that the principles underlying Popper’s philosophy of science can protect clinical research from corporate malfeasance in a capitalist economy. -/- Evidence-based medicine was a paradigm shift that is often praised as one of the greatest achievements of medicine in the twentieth century. This radical change in medical practice is based on epistemological hierarchies of evidence, from opinions (...) of respected authorities, mechanistic reasoning and reports of expert committees at the bottom to various levels of observational studies and finally to randomized, placebo-controlled clinical trials at the apex. Randomized, placebo-controlled clinical trials, recognized as the gold standard of clinical experimentation, generally maintain their position in the hierarchies because when well-designed and well-conducted, they provide a basis for assessing harms and benefits, and help deter extravagant claims of efficacy and safety. (shrink)

T. L. S. Sprigge produced an eclectic yet highly original system of metaphysics and ethics, a synthesis of panpsychism, absolute idealism, and utilitarianism, at a time in which orthodox analytical philosophy could only view this system as an anachronism of the nineteenth century. His critics claim that his philosophy has only historical interest to a small group of specialists in the relatively dormant tradition of British Idealism, that an attempt to defend his view of consciousness is a hopeless nonstarter, and (...) that his Spinozistic monism can have no relevance in our intellectual culture.1 Yet others have defended Sprigge as the "most independent of thinkers within the field of metaphysics" and salute him as "a .. (shrink)

This paper examines J. C. Maxwell’s electromagnetic field as the key idea for the development of A. N. Whitehead's event ontology. Whitehead viewed Maxwell's electromagnetism as the most revolutionary development of modern physics whereby events rather than substances become the basic units of reality.

There is perhaps no other branch of philosophy that has suffered as much scorn and ridicule as metaphysics. With bruised ego and much the worse for wear, it always re-emerges as methodologies become fatigued and the discussion of the central questions within exhausts itself. Even Bradley, the doyen of what was believed to be a metaphysics finished once and for all, can regain his place in the pantheon along side the likes of Plato, Descartes and Spinoza.

Traditionally, the three-pronged mission of our colleges and universities has been to provide high-quality education, encourage cutting-edge research, and promote professional and community service. The substitution of business-based policies for sound academic principles, however, has institutionalized a form of professional inequality that threatens all three. The growing distinction between tenured and tenure-track faculty members on the one hand and tenure-ineligible lecturers or part-time adjuncts on the other has produced an academic caste system that is undermining the raison d’être of our (...) institutions of higher learning. This system is capricious, discriminatory, and unjust. (shrink)

This chapter of Victor Lowe's Alfred North Whitehead: The Man and His Work, Volume II: 1910-1947 covers the development of Whitehead's philosophy of physics while he was Professor of Applied Mathematics at the Imperial College, London. Under the influence of Einstein's theory of relativity, Whitehead developed a theory of extension that explained the basis of the space-time manifold in terms of an ontology of events. Pan-physics was his term for the unification of the natural sciences as one general science.

W. V. Quine has been interpreted as a contemporary adaption of the American pragmatist movement that originated with Peirce, James and Dewey. While pragmatism plays some role in Quine's views on theory choice in science and ontology, I argue that this is insufficient for classifying his work with the early pragmatists or with recent revivals of pragmatism.

In this case study from litigation, we show how ghostwriting of clinical trial results can contribute to the manipulation of data to favor the study medication. Study 329 for paroxetine pediatric use was negative for efficacy and positive for harm. Yet the ghostwritten publication from this study concluded that paroxetine provided evidence of efficacy and safety and continues to be influential. Despite the role of named authors in revisions of the manuscript, the sponsor company remained in control of the message.

This paper is a deconstruction of a ghostwritten report of a randomized, double-blind, placebo-controlled efficacy and safety trial of citalopram in depressed children and adolescents conducted in the United States. Court documents revealed that protocol-specified outcome measures showed no statistically significant difference between citalopram and placebo. However, the published article concluded that citalopram was safe and significantly more efficacious than placebo for children and adolescents, with possible adverse effects on patient safety.

In his magnum opus, Process and Reality, Alfred North Whitehead claims a special affinity to Oxford philosopher Francis Herbert Bradley. McHenry clarifies exactly how much of Whitehead's metaphysics is influenced by and accords with the main principles of Bradley's absolute idealism. He argues that many of Whitehead's doctrines cannot be understood without an adequate understanding of Bradley, in terms of both affinities and contrasts. He evaluates the arguments between them and explores several important connections with William James, Josiah Royce, (...) George Santayana, Bertrand Russell, and Charles Hartshorne. (shrink)

In this introduction to philosophy, philosophers in their areas of specialization have produced essays written specifically for the novice. The collection includes traditional topics such as logic, metaphysics, epistemology, ethics, political philosophy, aesthetics, philosophy of religion , personal identity, and contemporary topics such as philosophy of mind and cognitive science.

In this essay I examine the concept of an event within the context of P. F. Strawson's distinction between descriptive and revisionary metaphysics. As opposed to the linguistic treatment of events in the descriptive approach of Strawson and Donald Davidson, I make a case for the revisionary approach of A. N. Whitehead and W. V. Quine, according to which events are basic rather than dependent on substances.

The problem of ghostwriting in corporate-sponsored clinical trials is of concern to medicine, bioethics, and government agencies. We present a study of the ghostwritten archival report of an industry-sponsored trial comparing antidepressant treatments for bipolar depression: GlaxoSmithKline (GSK) paroxetine study 352.